In 2002, Simm featured in the film 24 Hour Party People as New Order frontman Bernard Sumner. Simm also played the lead role of loan shark John Parlour in Tony Marchant's Never Never for Channel 4.
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In 2000, he starred in the opening episode of the BBC drama Clocking Off, written by Paul Abbott, with whom he would work again in 2002 when he starred as Cal McCaffrey in the multi-award-winning political thriller series State of Play. In 1999, he starred in the second series of The Lakes as well as appearing as Jip in the award-winning cult clubbing film Human Traffic and Michael Winterbottom's acclaimed Wonderland. In 1997, he won the lead role of Danny Kavanagh in the first series of The Lakes, a BBC series written by Jimmy McGovern.
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In 1996, he made his professional stage debut in the Simon Bent play Goldhawk Road at the Bush Theatre, directed by Paul Miller. He also made his feature film debut in Boston Kickout, beating Dennis Hopper to the Best Actor award at the Valencia Film Festival. This is considered his breakthrough role. In 1995, Simm played the troubled teenager Bill Preece in the acclaimed ITV police drama Cracker. His next project saw him take the role of Gary Kingston, a deluded murderer, in Chiller. He also made two series of the BBC sitcom Men of the World, playing the lead role of Kendle Bains. There then followed a variety of roles during which time he honed his craft in front of the camera, including a psycho in The Bill, as lovestruck schoolboy Richard Francis in Heartbeat, and a drugged-up burglar in The Locksmith.
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Simm made his professional acting debut in 1992 with the role of Joby Johnson in an episode of the TV series Rumpole of the Bailey (there had been an earlier part in the BBC drama Between the Lines where Simm was in one scene as PC Witty, but the scene was cut). Magic Alex released one album, Dated and Sexist, before splitting in 2005. He also played lead guitar on a few of McCulloch's solo live shows, including one at Wembley Arena as the main support to Coldplay. Simm plays guitar on the album Slideling by his friend, Echo & the Bunnymen singer Ian McCulloch. The group played support on two British tours with Echo & the Bunnymen. Throughout the 1990s and early 2000s, Simm was a founding member, songwriter, and guitarist with the rock band Magic Alex the band was named after "Magic Alex" Mardas, a Greek electronics engineer best known for his work with the Beatles. His acting teacher was Reuven Adiv, whom he credits as a major influence on his life. He then moved to London at the age of 19 to train at the Drama Centre London, where he studied Stanislavski's system of method acting. However, he soon decided that musical theatre did not interest him, so he joined an amateur dramatic group and honed his skills in his spare time, playing the title roles in Billy Liar and Amadeus. In 1986, he enrolled at Blackpool and The Fylde College in Blackpool for three years, and starred in Guys and Dolls and West Side Story at Blackpool's Grand Theatre.
He attended Edge End High School in Nelson, where he was inspired by his drama teacher.
He grew up in Lancashire in numerous places around northwest England, including Blackpool, Burnley, Colne, Manchester, and Nelson. From the age of 12, Simm sang and played guitar with his father on stage in the working men's clubs. His father, Ronald, was a musician from Manchester. John Simm was born on 10 July 1970 in Leeds, the eldest of three children.